The best selling album in 2008 in Uruguay was MURGAS 2008 by VARIOUS ARTISTS.
| Rank | Artist | Album | Released |
| 1 | VARIOUS ARTISTS | MURGAS 2008 | 2008 |
| 2 | NO TE VA GUSTAR | EL CAMINO MAS LARGO | 2008 |
| 3 | LA TRAMPA | EL MISERO ESPIRAL DEL ENCANTO | 2008 |
| 4 | PATITO FEO | LA VIDA ES UNA FIESTA (SOUNDTRACK) | 2008 |
| 5 | JOAN MANUEL SERRAT & JOAQUIN SABINA | DOS PAJAROS DE UN TIRO | 2007 |
| 6 | TEENANGELS | TEENANGELS II | 2008 |
| 7 | RICARDO ARJONA | 5TO PISO | 2008 |
| 8 | AGARRATE CATALINA | EL VIAJERA | 2008 |
| 9 | TABARÉ CARDOZO | EL MURGUERO ORIENTAL | 2008 |
| 10 | COLDPLAY | VIVA LA VIDA OR DEATH AND ALL HIS FRIENDS | 2008 |
Source: Cámara Uruguaya del Disco