The best selling album in 2010 in Ireland was NOW THAT'S WHAT I CALL MUSIC! 77 by NOW SERIES (UK).
| Rank | Artist | Album | Released |
| 1 | NOW SERIES (UK) | NOW THAT'S WHAT I CALL MUSIC! 77 | 2010 |
| 2 | THE SCRIPT | SCIENCE & FAITH | 2010 |
| 3 | TAKE THAT | PROGRESS | 2010 |
| 4 | MICHAEL BUBLÉ | CRAZY LOVE | 2009 |
| 5 | RIHANNA | LOUD | 2010 |
| 6 | LADY GAGA | THE FAME | 2008 |
| 7 | MUMFORD & SONS | SIGH NO MORE | 2009 |
| 8 | PAOLO NUTINI | SUNNY SIDE UP | 2009 |
| 9 | FLORENCE + THE MACHINE | LUNGS | 2009 |
| 10 | JUSTIN BIEBER | MY WORLD 2.0 / MY WORLDS | 2010 |
| 11 | GLEE CAST | GLEE: THE MUSIC, VOLUME 1 | 2009 |
| 12 | NOW SERIES (UK) | NOW THAT'S WHAT I CALL MUSIC! 76 | 2010 |
| 13 | EMINEM | RECOVERY | 2010 |
| 14 | KINGS OF LEON | COME AROUND SUNDOWN | 2010 |
| 15 | WESTLIFE | GRAVITY | 2010 |
| 16 | NOW SERIES (UK) | NOW THAT'S WHAT I CALL MUSIC! 75 | 2010 |
| 17 | SUSAN BOYLE | THE GIFT | 2010 |
| 18 | IMELDA MAY | MAYHEM | 2010 |
| 19 | IMELDA MAY | LOVE TATTOO | 2008 |
| 20 | THE BLACK EYED PEAS | THE E.N.D. | 2009 |
Source: IRMA